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KMID : 0371619980140010045
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Journal of Wonkwang Medical Science
1998 Volume.14 No. 1 p.45 ~ p.53
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The detection of Human Papilloma Virus in Cervical Neoplasia
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Ha Tae-Gyu
Kwon Sang-Chul
Kim Heung-Gon
Kwak Hyo-Il
Moon Hyung-Bae
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Abstract
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Cervical cancer is the most common gynecologic malignancy and leading cause of death in Korean women. Although the precise etiology of cervical cancer is unknown, epidemiologic studies suggest that venereally transmitted infectious agents could play an important role in the etiology of cervical cancer.
Recently, human papillomavirus(HPV) has been reported to be associated with neoplastic change. Cervical cytology is limited by its false negativity and this may be supplemented by other adjunctive test such as HPV test. It is therefore important to explore the use of HPV DNA detection as a primary or supplementary screening method and to determine whether HPV typing can be used as a predictor of a lesions clinical behavior. This study used the data gained from 145 women who diagnosed cervical neoplasia at the department of Obstetric and Gynecology in Wonkwang University Hospital from August in 1996 to July in 1998.
The results were as follows :
1. HPV DNA was detected in 104 cases of 145 patients (71.7%).
2. In cytological diagnosis, HPV DNA was detected in normal (53.5%), ASCUS (85.7%), LGSIL (94.1 %), HGSIL (74.6%) and invasive cervical cancer (80.0%).
3. In pathological diagnosis, HPV DNA was detected in chronic cervicitis (50.0%), CIN Ⅰ (52.9%), CIN Ⅱ (68.8%), CIN Ⅲ (81.3%) and invasive cervical cancer (68.8 %).
According to these results, HPV DNA detection by Hybrid Capture System may be a useful method in supplement the pitfalls of cervical cytology. To be clinically significant HPV test as a screening tool, the more population will be necessary for further study from now on.
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KEYWORD
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cervical neoplasia, HPV(human papillomavirus), Hybrid Capture System
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